. Author manuscript; available in PMC: 2014 Aug 1.

Published in final edited form as: Pharm Res. 2013 May 9;30(8):2063–2076. doi: 10.1007/s11095-013-1059-7

Table II.

First-order hydrolysis rate constants and half-lives of B-ACV, B-R-ACV and B-12HS-ACV in cornea, iris-ciliary body (ICB) and lens homogenates. Values are represented as mean ± standard deviation (n=4). Values reported are rounded off to significant digits at every step during calculations. ND = not determined due to rapid degradation.

Prodrugs	Cornea		ICB		Lens
Prodrugs	Rate constant (k×10³ min⁻¹ mg protein^-1)	Half-life (hrs)	Rate constant (k×10³ min⁻¹ mg protein^-1)	Half-life (hrs)	Rate constant (k×10³ min⁻¹ mg protein^-1)	Half-life (hrs)
B-R-ACV	1.84 ± 0.30	6.37 ± 1.01	3.75 ± 0.28	3.09 ± 0.24	0.84 ± 0.02	13.70 ± 0.34
B-12HS-ACV	1.78 ± 0.29	6.62 ± 1.08	3.58 ±0.70	3.45 ± 1.06	0.85 ± 0.16	13.85 ± 2.32
B-ACV	1.99 ± 0.21	5.80 ± 0.49	ND	-	ND	-