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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Pharm Res. 2013 May 9;30(8):2063–2076. doi: 10.1007/s11095-013-1059-7

Table II.

First-order hydrolysis rate constants and half-lives of B-ACV, B-R-ACV and B-12HS-ACV in cornea, iris-ciliary body (ICB) and lens homogenates. Values are represented as mean ± standard deviation (n=4). Values reported are rounded off to significant digits at every step during calculations. ND = not determined due to rapid degradation.

Prodrugs Cornea ICB Lens
Rate constant (k×103 min−1 mg protein-1) Half-life (hrs) Rate constant (k×103 min−1 mg protein-1) Half-life (hrs) Rate constant (k×103 min−1 mg protein-1) Half-life (hrs)
B-R-ACV 1.84 ± 0.30 6.37 ± 1.01 3.75 ± 0.28 3.09 ± 0.24 0.84 ± 0.02 13.70 ± 0.34
B-12HS-ACV 1.78 ± 0.29 6.62 ± 1.08 3.58 ±0.70 3.45 ± 1.06 0.85 ± 0.16 13.85 ± 2.32
B-ACV 1.99 ± 0.21 5.80 ± 0.49 ND - ND -