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. 2013 Jul 22;110(33):13492–13497. doi: 10.1073/pnas.1221555110

Fig. 4.

Fig. 4.

Comparisons between HLA allele frequencies and mortality from pH1N1 for various populations. (A) World map overlaying pH1N1 mortality ratios per million and HLA-A*24 frequencies for 34 countries. Analyses were performed on all countries for which both types of information, allele frequency and mortality from pH1N1, are publicly available. (B) pH1N1 mortality rates (y-axis) plotted against average HLA-A*24 frequencies (x-axis) for 34 countries. Mortality rates correlate with A*24 frequencies (r = 0.37, P = 0.031). (C) pH1N1 mortality rates (y-axis) are plotted against average HLA-A*68:01 (blue ×) and HLA-A*68:02 frequencies (magenta ○) (x-axis) for 32 and 22 countries, respectively. Mortality rates are correlated with A*68:01 frequencies (r = 0.45, P = 0.01), but not with A*6802 frequencies (P = 0.77). (D) pH1N1 mortality rates (y-axis) are plotted against average HLA-B*39 frequencies (x-axis) for 31 countries. Mortality rates correlate with B*39 frequencies (r = 0.36, P = 0.044). (E) pH1N1 mortality rates (y-axis) are plotted against average HLA-A*32 frequencies (x-axis) for 30 countries. Mortality rates negatively correlate with A*32 frequencies (r = −0.37, P = 0.047).