Table 1.

Examples of genes for which both promoter binding and gene expression were decreased by twofold or more by the DKQ mutation

Gene	Number of binding events			Relative gene expression		Kinetic type
	WT	K37Q	DKQ	K37Q/WT	DKQ/WT
MAP3K8	435	432	117	0.9	0.5	Slow
MYB	447	518	159	0.9	0.3	Slow
NFKB1	609	847	289	1.0	0.5	Slow
PTGES	651	549	140	1.2	0.1	Slow
TNFSF10B	734	684	228	0.9	0.4	Fast
IRF1	306	245	69	1.2	0.2	Fast

For this group of genes, promoter binding plays the dominant role in regulating gene expression. Both fast and slow genes were found in this group.