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. 2013 Jul 29;110(33):13528–13533. doi: 10.1073/pnas.1311565110

Fig. 3.

Fig. 3.

Endothelial-derived EETs stimulate tissue vascularization. (A) Whole-mount immunofluorescent CD31 staining of Matrigel plugs with no growth factors added shows increased vascularization in Tie2-CYP2J2-Tr, Tie2-CYP2C8-Tr, and sEH-null mice vs. WT mice. (Scale bars, 100 µm.) (B) Matrigel plug angiogenesis, quantified by flow cytometry, showing relative fraction of CD31+/CD45− ECs infiltrated into the plug. EC numbers (relative to WT) are increased in Tie2-CYP2J2-Tr, Tie2-CYP2C8-Tr, and sEH-null mice and decreased in Tie2-sEH-Tr mice relative to WT mice. n = 6–8 plugs per group. *P < 0.05 vs. WT.