Table 1.
Comparison of lipid profile, liver enzymes, and plaque thickness in normal and high-cholesterol diet animals (end of 2 months) and after stopping highcholesterol diet (end of 3 months)
| Groups |
Lipid profile (mg/dl) |
Liver enzymes |
Plaque thickness (µm) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| TC | TG | LDL | HDL | AST | ALT | AP | BUN | Cr | Aorta artery | |
| Normal-diet | 76.7 ± 23.2 | 179.3 ± 14.8 | 22.8 ± 6.4 | 68.7 ± 8.5 | 50.3 ± 6.4 | 68.0 ± 10.1 | 56.3 ± 1.9 | 5.0 ± 2.65 | 1.46 ± 0.20 | - |
| High-cholesterol diet | 467.6 ± 1002.1 | 1925.7 ± 2008.2* | 2232.8 ± 914.6* | 50.6 ± 2.7* | 83.0 ± 7.4* | 104.6 ± 7.5* | 230.0 ± 31.9* | 41.14 ± 1.03 | 2.02 ± 0.31* | 0.09 ± 0.04* |
| Control | 1406.0 ± 343.1* | 1037.3 ± 228.9* | 1073.3 ± 56.8* | 42.3 ± 4.8* | 86.3 ± 10.9 | 78.0 ± 2.0 | 145.7 ± 26.0 | 41.67 ± 0.88 | 2.03 ± 0.20 | 0.06 ± 0.01* |
| Atorvastatin | 813.7 ± 427.7*, ** | 386.7 ± 185.1* | 682.3 ± 368.2 | 54.0 ± 8.1 | 45.0 ± 4.9** | 57.7 ± 6.0** | 134.0 ± 15.1* | 42.67 ± 1.45 | 1.44 ± 0.43** | 0.06 ± 0.03* |
| Quince leaf extract | 511.7 ± 174.4*,** | 138.3 ± 68.3** | 534.0 ± 52.3*,** | 60.0 ± 6.1 | 45.0 ± 7.0** | 68.7 ± 2.7** | 121.5 ± 39.5* | 41.00±2.08 | 1.54±0.22** | 0.04± 0.01 |
TC: total cholesterol; TG: triglyceride; LDL: low density lipoprotein; HDL: high density lipoprotein; AST: aspartate transaminase; ALT: alanine transaminase; AP: alkaline phosphatase
*
compared with normal diet group
**
compared with control group