Table 1.
Table Comparison of Selected Studies Reporting Sex and Age Distribution for Patients With Neuromyelitis Optica or Aquaporin-4 Autoimmunity
| Source | Inclusion Criteria | Study Population (Patients, No.) | Female:Male Ratio | Onset Age, y | Positive AQP4-IgG Status, % |
|---|---|---|---|---|---|
| Collongues et al,7 2010 | Clinical diagnosis5 | Adult (125) | 3:1 | Mean, 34.5 (range, 4–66)a | 54b |
| Rivera et al,9 2008 | Clinical diagnosis1 | Adult (34) | 2.4:1 | Mean, 34 | Not tested |
| Bichuetti et al,10 2009 | Mostly clinical | Adult (41) | 2.4:1 | Mean, 32.6 (range, 20–60) | 41c |
| Ghezzi et al,8 2004 | Clinical diagnosis | Adult, pediatric (46) | 4.1:1 | Mean ± SD, 40 ± 16.3 (range, 12–77) | Not tested |
| Wingerchuk and Weinshenker,6 2003 | Clinical diagnosis1 | Adult, pediatric (80) | 2.5:1 | Median, 29 (monophasic) or 41 (relapsing) | Not tested |
| Jarius et al,12 2011 | AQP4-IgG seropositivity | Adult, pediatric (89) | 12.1:1 | Median, 39.5 (range, 14–79)d | 100 |
| Nagaishi et al,11 2011 | AQP4-IgG seropositivity | Adult, pediatric (583) | 10.7:1 | Median, 44 (range, 3–86) | 100 |
| McKeon et al,13 2008 | AQP4-IgG seropositivity | Pediatric (88) | 7:1 | Median, 12 (range, 4–18) | 100 |
| Current study | AQP4-IgG seropositivity | Adult, pediatric (56 464) | Unadjusted, 8.1:1; adjusted, 3.6:1 | Mean, 46 (16)d | 100 |
Abbreviation: AQP4, aquaporin-4.
a
Among the patients, 9.6% had onset before age 18 years and 16% had onset after age 50 years.
b
A total of 111 patients were tested.
c
A total of 17 patients were tested.
d
Refers to patient age at the time of AQP4-IgG testing.