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. 2013 May 29;4(7):647–650. doi: 10.1021/ml300454k

Table 1. Antiprion Potency (ELISA) and Cell Viability (Calcein AM) for Arylamide Analogues.

graphic file with name ml-2012-00454k_0007.jpg

  R1 Y Z R2 ELISA EC50 ± SEM (nM) calcein AM LD50 (nM) n
15 phenyl CH CH Me 520 ± 173 >5000 3
16 phenyl CH CH Et 221 ± 95 >9000 3
17 phenyl CH CH iPr 22 ± 4 >10000 4
20 2-pyridyl CH CH Et 365 ± 70 >10000 3
21 3-pyridyl CH CH Et 243 ± 29 >10000 3
22 4-pyridyl CH CH Et 743 ± 25 >10000 3
23 2-pyridyl CH CH iPr 165 ± 31 >10000 3
24 2-pyridyl N CH iPr 348 ± 129 >10000 3
25 2-pyridyl CH N iPr 677 ± 195 >10000 4
26 2-pyridyl CF CH iPr 411 ± 123 >10000 3
27 2-pyridyl CH CF iPr 334 ± 59 >10000 3