Table 1.

A and B moiety alkyl substituted nimesulide and their inhibition of SK-BR-3 cell growth

Compd		SKBR-3 cell growth inhibition (%) at 25μM
1	R1= CH3 R2= H	13.9 ± 1.6
2	R1= CH3 R2= CH3	13.7 ± 3.1
3	R2= H	16.6 ± 3.2
4	R2= CH3	17.1 ± 3.4
5	R2= H	39.3 ± 2.9
6	R2= CH3	57.5 ± 1.3
7	R2= H	29.1 ± 1.8
8	R2= CH3	6.1 ± 2.0
9	R2= H	13.8 ± 2.3
10	R2= CH3	10.6 ± 2.6
11	R2= H	61.6 ± 1.4
12	R2= CH3	62.8 ± 0.8
13	R2= H	66.5 ± 0.3
14	R2= CH3	35.2 ± 2.2
15	R2= H	31.3 ± 2.8
16	R2= CH3	43.0 ± 3.7

SK-BR-3 cells were treated with indicated compounds at 25μM for 48 h and cell viability was measured by MTT assay as described in the experimental section, n = 6.