Table 2.

A and B moiety aryl substituted nimesulide and their inhibition of SK-BR-3 cell growth

Compd		SKBR-3 cell growth inhibition (%) at 25μM
17	R2= H	34.1 ± 2.9
18	R2= CH3	38.5 ± 2.2
19	R2= H	53.6 ± 1.6
20	R2= CH3	31.5 ± 4.9
21	R2= H	55.4 ± 2.4
22	R2= CH3	41.7 ± 3.0
23	R2= H	65.7 ± 1.5
24	R2= CH3	53.0 ± 2.9
25	R2= H	27.8 ± 2.6
26	R2= CH3	37.6 ± 3.3
27	R2= H	26.4 ± 1.9
28	R2= CH3	26.8 ± 3.7
29	R2= H	24.6 ± 3.2
30*	R2= CH3	81.6 ± 1.0
31	R2= H	41.8 ± 1.4
32	R2= CH3	20.9 ± 5.0
33	R2= H	47.7 ± 3.1
34	R2= CH3	7.0 ± 1.0
35	R2= H	42.7 ± 1.9
36	R2= CH3	13.4 ± 2.2
37	R2= H	36.7 ± 1.2
38	R2= CH3	38.6 ± 3.4
39	R2= H	28.6 ± 2.9
40	R2= CH3	29.0 ± 4.6
41	R2= H	53.8 ± 2.1
42	R2= CH3	61.4 ± 1.1
43	R2= H	63.7 ± 1.3
44*	R2= CH3	89.7 ± 0.4

SK-BR-3 cells were treated with indicated compounds at 25μM for 48 h and cell viability was measured by MTT assay as described in the experimental section, n = 6.

^*Significantly active compounds