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. Author manuscript; available in PMC: 2013 Aug 19.
Published in final edited form as: J Comb Chem. 2008 Apr 2;10(3):475–483. doi: 10.1021/cc700138n

Table 6.

Inhibition of SK-BR-3 cells growth by D moiety substituted nimesulide derivatives

Compd graphic file with name nihms460039u5.jpg SKBR-3 cell growth inhibition (%) at 25μM
73 R= H 62.8 ± 1.0
74 graphic file with name nihms460039t71.jpg 14.6 ± 1.9
75* graphic file with name nihms460039t72.jpg 73.2 ± 1.2
76* graphic file with name nihms460039t73.jpg 75.4 ± 0.4

SK-BR-3 cells were treated with indicated compounds at 25μM for 48 h and cell viability was measured by MTT assay as described in the experimental section, n = 6.

*

Significantly active compounds