Table 6.
Inhibition of SK-BR-3 cells growth by D moiety substituted nimesulide derivatives
Compd |
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SKBR-3 cell growth inhibition (%) at 25μM |
---|---|---|
73 | R= H | 62.8 ± 1.0 |
74 |
![]() |
14.6 ± 1.9 |
75* |
![]() |
73.2 ± 1.2 |
76* |
![]() |
75.4 ± 0.4 |
SK-BR-3 cells were treated with indicated compounds at 25μM for 48 h and cell viability was measured by MTT assay as described in the experimental section, n = 6.
Significantly active compounds