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. 2013 Aug 9;4:111–121. doi: 10.2147/JBM.S33142

Table 2.

Classification of syndromes and conditions accompanied by hypereosinophilia

Proposed terminology Pathogenesis/definition
Idiopathic hypereosinophilic syndrome No underlying cause of hypereosinophilia.
Primary (clonal/neoplastic) hypereosinophilic syndrome Underlying stem cell, myeloid or eosinophilic neoplasm (WHO criteria).
Secondary (reactive) hypereosinophilic syndrome Underlying condition/disease in which eosinophils are non-clonal cells.
 Hypereosinophilia is triggered by cytokines.
Subvariant: lymphoid variant hypereosinophilic syndrome (clonal T-cells identified as the only potential cause).

Note: Adapted from J Allergy Clin Immunol, 130(3), Valent P, Klion AD, Horny HP, et al. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes, 607–612.e9. Copyright (2012), with permission from Elsevier.7

Abbreviation: WHO, World Health Organization.