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. 2013 Aug 19;8(8):e72164. doi: 10.1371/journal.pone.0072164

Figure 1. The global BDNF-dependent proteome response is altered in SORLA-deficient neurons.

Figure 1

(A) A prototypic two-dimensional polyacrylamid gel of proteins from Sorl1−/− primary cortical neurons stained with silver nitrate. Significant protein spot alterations in response to BDNF treatment (150 ng/ml for 2 days) in wild type neurons (red circles), in SORLA-deficient neurons (blue circles) or in both genotypes (green circles) as compared to untreated samples are indicated. (n = 6 biological replicates per genotype; Student’s t-test p<0.05). (B) Total number of protein spots altered in primary cortical neurons of the indicated genotypes in response to BNDF treatment as exemplified in panel A. (n = 6 biological replicates per genotype; Student’s t-test p<0.05).