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. 2013 Aug 19;8(8):e72164. doi: 10.1371/journal.pone.0072164

Figure 5. Loss of SORLA aggravates neuromotoric deficits in Huntington’s disease mice.

Figure 5

(A) At 10 weeks of age, Huntington’s disease mice deficient for SORLA (HD82xSorl1−/−) display aggravated hind limb clasping compared with HD82 control littermates (HD82xSorl1+/+). (B, C) Worsening of neuromotoric deficits due to loss of SORLA is also seen when comparing (HD82xSorl1−/−) animals with (HD82, Sorl1+/+) controls of either sex at 10 (B) and 18 weeks of age (C) during consecutive days of rotarod performance test (n = 8–9, Mann-Whitney-U). (D) No difference in rotarod performance is seen comparing 10 weeks-old Sorl1+/+ and Sorl1−/− mice matched for age and sex (n = 10, Mann-Whitney-U).