Table 5. HIV-1 drug-resistance mutations in patients <15 years old (n = 11) a .
| ART | n | Amino acid mutations associated with | |
| NNRTI resistance | NRTI resistance | ||
| Naïve | 5 | − | − |
| 2 | V90I, V106I | − | |
| 2 | V90I | − | |
| 1 | K103N, G190S | − | |
| d4T+3TC+EFV | 1 | K101E, V106I, V108I, G190S | M184V |
ART, antiretroviral therapy; d4T, stavudine; EFV, efavirenz; NNRTI, non-nucleoside reverse-transcriptase inhibitor; NRTI, nucleoside reverse-transcriptase inhibitor; and 3TC, lamivudine.
a
HIV-1 drug-resistance mutations were detected according to the latest definition of the International AIDS Society-USA panel [10]. For ART-naïve patients, transmitted drug-resistance (shown in bold and underlined) was detected according to the latest definition of the WHO drug-resistance surveillance [11].