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. 2013 Aug 19;8(8):e72976. doi: 10.1371/journal.pone.0072976

Figure 1. Schematic of the circuit hypothesis for ethanol-enhancement of synaptic GABA release from Golgi neurons.

Figure 1

A. Schematic of the connectivity between cerebellar granule cells and Golgi cells including the inhibitory connections between Golgi cells identified in recent studies [33]. Location of extrasynaptic GABARs in granule cell somata and parallel fiber axons is illustrated. Prediction (right panel), illustrates the proposed changes in neuronal activity in the circuit following increased activation of parallel fiber GABARs. B. Hypothesized effect of GluR antagonists on circuit activity following increase in activation of granule cell extrasynaptic GABARs. Red X indicates blocked glutamatergic synapses. C. Predicted effects of GABAR antagonists on granule and Golgi cell activity following increased activation of granule cell extrasynaptic GABARs. Red X indicates blocked GABA synapses and orange X denotes block of both somato-dendritic and axonal extrasynaptic GABARs.