Figure 5. GABAR δ-subunit selective agonist THIP increases sIPSC frequency.

A. Representative current traces illustrate enhancement of sIPSC frequency and tonic GABA currents by THIP (1 µM). To the right are histograms of all points in each segment. Tonic GABA currents were measured as the baseline current blocked by GABAR antagonist gabazine (10 µM). Gaussian fits to current trace under each condition are superimposed (right panel). Dashed lines indicate the mean baseline currents and the difference in baseline currents measured as tonic GABA currents are noted. B. Summary data show the effect of 500 nM and 1 µM THIP on granule cell sIPSC frequency. C. Histogram shows the amplitude of tonic GABA currents in ACSF, 500 nM and 1 µM THIP measured simultaneously during the recordings in B. * indicates p<0.05 by paired t-test, # indicates p<0.05 by one-way repeated measures ANOVA followed by post-hoc analyses by Holm-Sidak method.