Table 1. Demographic characteristics of whole cohort.
Demographic characteristics | Whole cohort | |
Number of patients n (%) | 70 (100) | |
Age (Years) | Mean (median)range | 6.5 (5.0) 0.1–19.9 |
Body weight (Kg) | Mean (median)range | 27.0 (20.8) 4.3–95.6 |
Gender n (%) | Male | 41(58.6) |
Females | 29 (41.4) | |
Diagnosis n (%) | AML | 26 (37.1) |
MDS | 12 (17.1) | |
Immunodeficiency | 11 (15.7) | |
ALL | 9 (12.9) | |
Metabolic disease | 5 (7.1) | |
Hemophagocytic syndrome | 5 (7.1) | |
Hemoglobinopathies | 1 (1.4) | |
Neuroblastoma | 1 (1.4) | |
Conditioning regimen n (%) | Bu+Cy | 53 (75.7) |
Bu+Cy+Mel | 3 (4.3) | |
Bu+Cy+VP16 | 7 (10) | |
Bu+Flu | 4 (5.7) | |
Bu+Mel | 3 (4.3) | |
Disease status in malignancies n (%) | First acute phase of the disease | 1(2.7) |
First CR | 18(50.0) | |
second CR | 12(33.3) | |
third or more CR | 2(5.5) | |
First Relapse | 3(8.3) | |
HLA Matching n (%) | 3/6 | 2 (2.9) |
4/6 | 20 (28.6) | |
5/6 | 28 (40) | |
6/6 | 16 (22.9) | |
7/8 | 1 (1.4) | |
8/8 | 2 (2.9) | |
7/10 | 1 (1.4) | |
HLA match compatibility n (%) | MRD | 2(2.8) |
MUD | 16 (22.9 ) | |
MMU | 52 (74.3) | |
Days after transplant | Mean (median) | 1064.4 (815.0) |
Nucleated cells injected (108/kg) | Mean (median)range | 2.1 (1.4) 0.16–18.0 |
CD34+ cells injected (108/kg) n = 64 | Mean (median)range | 0.02 (0.004) 0.0005–0.14 |
Abbreviations: ALL: acute lymphoblastic leukemia; AML: acute myeloid leukemia; ATG: anti-thymocyte globulin; Bu: busulfan; Cy: cyclophosphamide; CR: Complete remission; Flu: fludarabine; MDS: myelodisplastic syndrome; Mel: melphalan; MMU: mismatch unrelated; MRD: matched related donor; MTX: methotrexate; MUD: matched unrelated donor; VP16: etoposide.