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. 2013 Aug 19;8(8):e72332. doi: 10.1371/journal.pone.0072332

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© 2013 Han et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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To compare with Bonferroni correction and FDR procedure, we drew histogram of p-values in log-scale whose correlation coefficients are negative, showing the thresholding p-value of Bonferroni correction with α = 0.10, (thin solid vertical line), and the maximum of uncorrected p-values of network connections in the proposed cluster-based correction, p _max (thick solid vertical line), for patients with svMCI (A) and SVaD (B). We note that the thresholding p-values of the FDR procedure with q = 0.05 and 0.1 cannot be shown in log-scale, because they both are exactly zero, leading no significant findings. To compare with extreme statistics, we drew the histogram of raw correlation coefficients (Spearman, partial correlation adjusting age and gender), showing 10% threshold of the extreme statistics, (thin solid vertical line), along with the initial threshold, (thick solid vertical line), in patients with svMCI (C) and SVaD (D), where dotted vertical line indicates the zero correlation coefficient.

Inline graphic — To compare with Bonferroni correction and FDR procedure, we drew histogram of p-values in log-scale whose correlation coefficients are negative, showing the thresholding p-value of Bonferroni correction with α = 0.10, (thin solid vertical line), and the maximum of uncorrected p-values of network connections in the proposed cluster-based correction, p _max (thick solid vertical line), for patients with svMCI (A) and SVaD (B). We note that the thresholding p-values of the FDR procedure with q = 0.05 and 0.1 cannot be shown in log-scale, because they both are exactly zero, leading no significant findings. To compare with extreme statistics, we drew the histogram of raw correlation coefficients (Spearman, partial correlation adjusting age and gender), showing 10% threshold of the extreme statistics, (thin solid vertical line), along with the initial threshold, (thick solid vertical line), in patients with svMCI (C) and SVaD (D), where dotted vertical line indicates the zero correlation coefficient.