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. 2013 Aug 19;8(8):e71400. doi: 10.1371/journal.pone.0071400

Figure 5. Cardiac function in isolated perfused hearts 24 h after trauma.

Figure 5

(A) Nonlethal mechanical trauma resulted in significant decrease in left ventricular developed pressure(LVDP), which was prevented by administration of rapamycin (RAPA) 30 min before trauma. (B and C) Mechanical trauma resulted in significant decrease in the maximal positive and negative values of the instantaneous first derivative of left ventricular pressure (LVP, +dP/dtmax and -dP/dtmax) in isolated perfused hearts 24 h after trauma, which was prevented by administration of RAPA 30 min before trauma. Data are expressed as Mean±SD (n = 6). * p<0.05; ** p<0.01.