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. 2013 Aug 19;8(8):e71399. doi: 10.1371/journal.pone.0071399

Figure 1. Combined effects of increasing numbers of isolated fasting hyperglycaemia-associated risk alleles for TCF7L2, CDKN2BAS, KCNQ1, FTO and GCKR.

Figure 1

A: The isolated fasting hyperglycaemia-associated risk allele distribution in controls, participants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia. Each additional risk allele increased the risk of isolated fasting hyperglycaemia by 1.24-fold (p<0.0001) (B) but not the risk of isolated postprandial hyperglycaemia (C). OR and 95% CI plotted on the y-axis for the corresponding number of risk alleles on the x-axis (black circles  =  risk of isolated fasting hyperglycaemia; white circles  =  risk of isolated postprandial hyperglycaemia). B: Participants harboring five or more risk alleles had a 2.23-fold increased risk for isolated fasting hyperglycaemia (p<0.0001) compared with the reference group. C: However, risk for isolated postprandial hyperglycaemia was not increased as risk allele number increased. IFH, isolated fasting hyperglycemia; IPH, isolated postprandial hyperglycemia.