Table 3. SNPs significantly associated with isolated postprandial hyperglycemia in Hans.
Minor/major | Allelic | Genotypic | Genotypic | |||
Gene | SNP | allelea | associationb | associationc | associationd | |
TCF7L2 | rs7903146 | T/C | OR (95%CI) | 1.507 (1.187,1.914) | 1.485 (1.158,1.906) | 1.438 (1.080,1.888) |
p | 0.0007 | 0.0019 | 0.0123 | |||
Empirical p | 0.0230 | |||||
KCNQ1 | rs2237895 | C/A | OR (95%CI) | 1.154 (1.030,1.294) | 1.153 (1.025,1.296) | 1.181 (1.038,1.343) |
p | 0.0137 | 0.0174 | 0.0115 | |||
Empirical p | 0.3317 | |||||
GCKR | rs780094 | G/A | OR (95%CI) | 0.904 (0.815,1.003) | 0.891 (0.801,0.991) | 0.895 (0.796,1.006) |
p | 0.0574 | 0.0331 | 0.0627 | |||
Empirical p | 0.8182 | |||||
CDKAL1 | rs7756992 | A/G | OR (95%CI) | 1.209 (1.089,1.342) | 1.217 (1.092,1.355) | 1.233 (1.095,1.389) |
p | 0.0004 | 0.0004 | 0.0005 | |||
Empirical p | 0.0180 | |||||
TP53INP1 | rs896854 | A/G | OR (95%CI) | 1.109 (0.996,1.235) | 1.129 (1.009,1.263) | 1.099 (0.971,1.245) |
p | 0.0601 | 0.0348 | 0.1360 | |||
Empirical p | 0.8282 | |||||
PRC1 | rs8042680 | C/A | OR (95%CI) | 1.709 (1.045,2.793) | 1.758 (1.063,2.908) | 1.555 (0.917,2.639) |
p | 0.0307 | 0.0279 | 0.1016 | |||
Empirical p | 0.6164 | |||||
HHEX | rs1111875 | G/A | OR (95%CI) | 1.105 (0.987,1.238) | 1.102 (0.981,1.238) | 1.151 (1.013,1.309) |
p | 0.0838 | 0.1027 | 0.0309 | |||
Empirical p | 1.0000 |
Risk alleles for type 2 diabetes in the Caucasian descent population are denoted in bold. OR and 95% CI are reported for the allele with higher type 2 diabetes risk previously reported for Caucasians using χ2 or an additive model in logistic regression.
Comparison of the allelic distribution between isolated postprandial hyperglycemia and controls.
Comparison of the genotype distribution between isolated postprandial hyperglycemia and controls after adjusting for region, age and gender.
Comparison of the genotype distribution between isolated postprandial hyperglycemia and controls after adjusting for region, age, gender and BMI.
Associations of the rest SNPs with isolated postprandial hyperglycemia are shown in Table S5.
Empirical p values were calculated through 1,000 permutations. p values <0.05 are shown in bold.