Table 3. SNPs significantly associated with isolated postprandial hyperglycemia in Hans.

		Minor/major		Allelic	Genotypic	Genotypic
Gene	SNP	allelea		associationb	associationc	associationd
TCF7L2	rs7903146	T/C	OR (95%CI)	1.507 (1.187,1.914)	1.485 (1.158,1.906)	1.438 (1.080,1.888)
			p	0.0007	0.0019	0.0123
			Empirical p	0.0230
KCNQ1	rs2237895	C/A	OR (95%CI)	1.154 (1.030,1.294)	1.153 (1.025,1.296)	1.181 (1.038,1.343)
			p	0.0137	0.0174	0.0115
			Empirical p	0.3317
GCKR	rs780094	G/A	OR (95%CI)	0.904 (0.815,1.003)	0.891 (0.801,0.991)	0.895 (0.796,1.006)
			p	0.0574	0.0331	0.0627
			Empirical p	0.8182
CDKAL1	rs7756992	A/G	OR (95%CI)	1.209 (1.089,1.342)	1.217 (1.092,1.355)	1.233 (1.095,1.389)
			p	0.0004	0.0004	0.0005
			Empirical p	0.0180
TP53INP1	rs896854	A/G	OR (95%CI)	1.109 (0.996,1.235)	1.129 (1.009,1.263)	1.099 (0.971,1.245)
			p	0.0601	0.0348	0.1360
			Empirical p	0.8282
PRC1	rs8042680	C/A	OR (95%CI)	1.709 (1.045,2.793)	1.758 (1.063,2.908)	1.555 (0.917,2.639)
			p	0.0307	0.0279	0.1016
			Empirical p	0.6164
HHEX	rs1111875	G/A	OR (95%CI)	1.105 (0.987,1.238)	1.102 (0.981,1.238)	1.151 (1.013,1.309)
			p	0.0838	0.1027	0.0309
			Empirical p	1.0000

^aRisk alleles for type 2 diabetes in the Caucasian descent population are denoted in bold. OR and 95% CI are reported for the allele with higher type 2 diabetes risk previously reported for Caucasians using χ2 or an additive model in logistic regression.

^bComparison of the allelic distribution between isolated postprandial hyperglycemia and controls.

^cComparison of the genotype distribution between isolated postprandial hyperglycemia and controls after adjusting for region, age and gender.

^dComparison of the genotype distribution between isolated postprandial hyperglycemia and controls after adjusting for region, age, gender and BMI.

Associations of the rest SNPs with isolated postprandial hyperglycemia are shown in Table S5.

Empirical p values were calculated through 1,000 permutations. p values <0.05 are shown in bold.