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. 2013 Aug 19;8(8):e71701. doi: 10.1371/journal.pone.0071701

Figure 8. Reorganization of vestibulospinal connections to lumbar medial and lateral motor columns following SCC.

Figure 8

(A) Schematic of the ex vivo preparation of the brain stem and spinal cord showing the site of vestibular nerve stimulation (VIII N Stim) and the CGDA labeling of the L5 ventral root. (B) Low temporal resolution (4 Hz frame rate) optical recordings of calcium transients elicited in LMC MNs (black traces) and MMC MNs (red traces) in response to train stimulation of the vestibular nerve (same parameters as in Fig. 6) in one sham control mouse (B1) and two SCC mice (B2, B3) 4 days after surgery/injury. ΔF/F represents fluorescence change in % relative to baseline. The small green traces (DR stim) show responses to stimulation of the L5 dorsal root. Insets above the MMC traces show the apparent reorganized synaptic connectivity from lateral vestibulospinal tract (VST) to LMC and MMC.