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. 2013 Aug 19;8(8):e71392. doi: 10.1371/journal.pone.0071392

Table 3. Estimated associations for ∑DEHP and MnBP with IR markers.

Glucose Insulin HOMA
Model Metabolite β 95% CI P-Value β 95% CI P-Value β 95% CI P-Value
1 ∑DEHP 0.10 0.003, 0.20 0.044 0.67 −0.004, 1.34 0.051 0.25 0.02, 0.48 0.031
MnBP 0.04 −0.06, 0.13 0.436 0.33 −0.33, 0.98 0.326 0.13 −0.09, 0.35 0.260
2 ∑DEHP 0.11 0.01, 0.21 0.032 0.67 −0.02, 1.35 0.058 0.25 0.02, 0.48 0.037
MnBP 0.05 −0.05, 0.15 0.295 0.32 −0.35, 0.99 0.351 0.13 −0.10, 0.36 0.255
3 ∑DEHP 0.11 0.01, 0.22 0.033 0.70 0.01, 1.40 0.047 0.26 0.01, 0.51 0.040
MnBP 0.06 −0.04, 0.17 0.241 0.38 −0.30, 1.07 0.273 0.16 −0.09, 0.40 0.211

β and 95% confidence interval (CI) were obtained in single pollutant models of ∑DEHP and MnBP. Changes in glucose, insulin, and HOMA indices by a log change of ∑DEHP and MnBP were obtained by model; Model 1 adjusted for age, sex, BMI, educational attainment, exercise, and cotinine level; model 2 adjusted for model 1 variables plus PM10 on lag day 4, O3 on lag day 5, NO2 on lag day 7, and outdoor temperature and dew point in the day; model 3 adjusted for model 2 variables plus total caloric and fat intake. ∑DEHP, molar sum of mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP); MnBP, mono-n-butyl phthalate; HOMA, homeostatic model assessment.