Figure 1.

PSCA and Oct-4 expression in the benign and malignant lesions of gallbladder. EnVision immunohistochemistry, original magnification ×200. PSCA and Oct-4 positive reaction was mainly localized in the cytoplasm. (a) PSCA positive expression in poorly differentiated gallbladder adenocarcinoma; (b) PSCA positive expression in severe atypical hyperplasia of gallbladder epithelium of peritumoral tissues. (c) PSCA positive expression in adenoma with moderate dysplasia; (d) Oct-4 positive expression in moderately differentiated gallbladder adenocarcinoma; (e) Oct-4 positive expression in severe atypical hyperplasia of gallbladder epithelium of peritumoral tissues; (f) Oct-4 positive expression in moderate atypical hyperplasia of gallbladder epithelium in chronic cholecystitis; (g) Oct-4 positive staining with 4 scores is observed in adenomatous polyps with moderate atypical hyperplasia; (h) Oct-4 positive staining with 4 scores is observed in chronic cholecystitis with moderate atypical hyperplasia.