Table 1.
Chemical and physicochemical properties of liposomes containing or not UAa.
| Formulation | Mean diameter (nm) | Zeta potential (mV) | UA entrapment (mg/mL) |
|---|---|---|---|
| SpHL 20Bb | 105.8 ± 3.3 | 3.2 ± 1.0 | — |
| SpHL 20UA1c,h | 191.1 ± 6.4 | 1.2 ± 1.4 | 0.77 ± 0.01 |
| SpHL 20UA0.5d,h | 149.4 ± 1.5 | 1.7 ± 2.6 | 0.38 ± 0.01 |
| SpHL 40Be | 107.3 ± 2.6 | 2.9 ± 0.4 | — |
| SpHL 40UA1f,h | 140.4 ± 1.2 | 4.1 ± 1.3 | 0.78 ± 0.05 |
| SpHL 40UA0.5g,h | 122.8 ± 3.1 | 4.4 ± 0.5 | 0.35 ± 0.04 |
aValues are expressed as mean ± S.D. (n = 3). bLipid concentration is equal to 20 mM, without UA. cLipid concentration is equal to 20 mM, and UA concentration is of 1 mg/mL. dLipid concentration is equal to 20 mM, and UA concentration is of 0.5 mg/mL. eLipid concentration is equal to 40 mM, without UA. fLipid concentration is equal to 40 mM, and UA concentration is of 1 mg/mL. gLipid concentration is equal to 40 mM, and UA concentration is of 0.5 mg/mL. hThere is a significant difference among the mean diameter values of SpHL samples containing UA and the respective SpHL samples without UA at the same lipid concentration (P < 0.05).