Table 1.

Genomic and proteomic features of basal-like breast cancer (data from TCGA [7]).

Pathways and analysis	Aberrations
TP53 pathway	TP53 mut (84%); gain of MDM2 (14%)
PIK3CA/PTEN pathway	PIK3CA mut (7%); PTEN mut/loss (35%); INPP4B loss (30%)
RB1 pathway	RB1 mut/loss (20%); cyclin E1 amp (9%); high expression of CDKN2A; low expression of RB1
Copy number	Most aneuploid; high genomic instability; 1q, 10p gain; 8p, 5q loss; MYC focal gain (40%)
Proteomic analysis by reverse phase protein array	High expression of DNA repair proteins, PTEN and INPP4B loss signature (pAKT)