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. Author manuscript; available in PMC: 2013 Aug 20.
Published in final edited form as: J Endocrinol. 2009 Jul 8;203(1):75–85. doi: 10.1677/JOE-09-0179

Figure 7. Leptin-induced thymic protection is characterized by increased thymocyte proliferation and decreased thymocyte apoptosis.

Figure 7

Female C57BL/6 mice were administered either saline or leptin (1 µg/g body weight, IP) and simultaneously challenged with either saline or E. coli LPS (100 µg/mouse, IP). Frequency of DP thymocytes (A) and frequency of DN thymocytes (B) were determined one and three days post treatment, respectively. Frequency of DN thymocytes positive for BrdU (C) was determined three days post treatment. Frequency of DP thymocytes positive for active caspase 3 was determined in C57BL/6 (D) or db/db (E) mice one day post treatment. Percent reduction of active caspase 3-positive cells in LPS challenged mice with leptin treatment in C57BL/6 and db/db mouse strains (F). Data presented are mean ± SD from five mice per group.* p ≤ 0.05 compared with saline-treated controls. ** p ≤ 0.05 compared with LPS-treated controls.