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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Hypertension. 2013 Jan 21;61(3):593–601. doi: 10.1161/HYPERTENSIONAHA.111.00514

Figure 4.

Figure 4

HO-3867 attenuates left-heart failure (LHF)-induced increase in pulmonary artery pressure. LHF was induced in rats by permanent ligation of left anterior descending coronary artery for 4 weeks. HO-3867 was administered in the feed throughout the period. Hemodynamic (pressure) measurements were performed at the end of 4 weeks postligation. A, Representative tracings of the pulmonary artery pressure (PAP). B, Left-ventricular systolic pressure (LVSP). C, Right-ventricular systolic pressure (RVSP). D, Mean pulmonary arterial pressure (mPAP). Data represent mean±SD; n=6 animals/group. *P<0.05. The results show HO-3867 significantly attenuates the increase in mPAP observed in the LHF group.