FIG. 4.

Liver injury induced by AAV8-H1- and AAV8-U6-encoded shRNAs in ICR/HBV mice. Groups of ICR/HBV mice (n=8) were injected intravenously with 10¹² vg per mouse of different AAV8-H1 or AAV8-U6 vectors as in Figure 2, and serum samples collected at the indicated times for measurement of ALT activity (a) and albumin levels (b). The data (mean±SD) are for one representative result from two independent experiments. The dashed lines represent the mean value for ALT activity (a) or albumin levels (b) in untreated ICR/HBV mice (n=6). ALT, alanine aminotransferase.