Table 1.

Randomized controlled trials of probiotics on IBS

Probiotic	Number of subjects	Duration	Result	Reference
B. infantis 35624	77	8 weeks	Pain, IBS score, bowel movement difficulty ↓	7
	362	4 weeks	Abdominal pain, IBS score, distension, incomplete evacuation, straining, flatulence ↓	8
B. animalis DM 173010	274	6 weeks	Stool frequency in subjects with <3 stools/week ↑	10
B. bifidum MIMBb75	122	4 weeks	IBS symptoms, pain, discomfort, distension, bloating, urgency, digestive disorder ↓	9
L. plantarium 299V	60	4 weeks	Flatulence ↓	11
	20	4 weeks	IBS score, abdominal pain ↓	13
	12	4 + 4 weeks	↔	18
L. rhamnosus GG	24	8 + 8 weeks	↔	12
	50 children	6 weeks	Abdominal distention ↓	14
	104 children	4 weeks	Treatment success ↑; abdominal pain frequency ↓	15
	141 children	12 weeks	Treatment success ↑; abdominal pain ↓	17
L. acidophilus-SDC 2012, 2013	40	4 weeks	Treatment success ↑; abdominal pain and discomfort ↓	16
L. acidophilus	61	2 weeks	↔	19
L. reuteri ATCC 55730	54	6 months	↔	20
L. plantarum MF1298	16	3 + 3 weeks	IBS sum score ↑	21
S. boulardii	67	4 weeks	↔	22
	35	30 days	↔	23
Streptococcus faecium	54	4 weeks	Clinical improvement ↑	24