Table 2.

Randomized controlled trials of probiotic mixtures on IBS

Probiotic mixture	Number of subjects	Duration	Result	Reference
L. rhamnosus GG combinationa	103	6 months	IBS score ↓	25
	86	5 months	IBS score ↓	26
VSL#3b	25	8 weeks	Bloating ↓	27
	48	4 weeks	Flatulence, colonic transit ↓	28
	59 children	6 weeks	IBS symptoms ↓	29
L. plantarum LP 01 + B. breve BR 03 or L. plantarum LP 01 + L. acidophilus LA 02	70	4 weeks	IBS symptoms, pain ↓	30
L. acidophilus CUL60 + L. acidophilus CUL21 + B. lactis CUL34 + B. bifidum CUL20	52	8 weeks	IBS symptoms, pain ↓	31
B. bifidum BGN4 + B. lactis AD011 + L. acidophilus AD031 + L. casei IBS041	70	8 weeks	Abdominal pain ↓	32
B. longum LA 101 + L. acidophilus LA 102 + L. lactis LA 103 + S. thermophilus LA	100	4 weeks	↔	33

^aLGG^® combination = L. rhamnosus GG, L. rhamnosus LC705, P. freudenreichii spp. shermanii JS, and B. breve Bb99 or B. animalis spp. lactis Bb12.

^bVSL#3 = B. longum, B. infantis, B. breve, L. acidophilus, L. casei, L. bulgaricus, L. plantarum, and S. salivarius subsp. thermophilus.