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. Author manuscript; available in PMC: 2013 Aug 20.
Published in final edited form as: Curr Cancer Drug Targets. 2009 Jun;9(4):566–571. doi: 10.2174/156800909788486759

Fig. (1). Molecular mechanisms involved in p50-mediated apoptosis by arsenite.

Fig. (1)

Arsenite exposure leads to IKK activated, which will interact with p50 to form IKK/p50 complex. IKK/p50 complex mediates GADD45α de-ubiquitination and protein accumulation. Accumulated GADD45α protein activates MEKK4/JNKs pathway and in turn results in cell apoptosis.