Skip to main content
. Author manuscript; available in PMC: 2013 Aug 20.
Published in final edited form as: Curr Cancer Drug Targets. 2009 Jun;9(4):566–571. doi: 10.2174/156800909788486759

Fig. (2). The activity of p50 homodimer and its functions.

Fig. (2)

The p50 can be generated from p105 with removal of C-terminal by 26S proteasome. The heterodimer of p105/p50 can be cleaved by 26S proteasome to active p50/p50 homodimer. This homodimer become an inactive complex by binding to p105, and this complex also can be cleaved to p50 homodimer by 26S proteasome. A. p50 homodimer can activate MAPKs or invoved in the up-regulation of Cyclin D1 expression and in turn promotes cell proliferation. B. p50 homodimer associated with HDAC1 can bind to target gene promoter and represses its target gene expression. C. Exposed to special chemical materials such as asenite, activated p50 homodimer can increase in GADD45α protein de-ubiquitination, and protect it from degradation, subsequently leads to JNKs activation and in turn results in cell apoptosis. D. p50 homodimer can also bind with Bcl3 and up-regulates the expression of its target gene expression, and protects cell from undergo to apoptosis.