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. Author manuscript; available in PMC: 2013 Aug 20.
Published in final edited form as: Pediatr Diabetes. 2012 Jun 14;13(8):656–660. doi: 10.1111/j.1399-5448.2012.00874.x

Figure 1.

Figure 1

Sensitivity of wild-type (WT) and mutant KATP channels to ATP inhibition. Dose-response curves were obtained by exposing channels to different concentrations of ATP in Kint solutions and are fit by the Hill equation: relative current = 1/(1+{[ATP]/IC50}H) with IC50 = 14 μM (WT), and 44 μM ([S225T, del]+WT) and H = 1.6 (WT) and 1.2 ([S225T, del]+ WT).