Figure 1.

Glucose metabolism after renal transplantation. OGTT-derived measures are shown from subjects at 3 months posttransplant (TIP study patients = early kidney transplant recipients [KTRs]) and ≥6 months posttransplant (TAHG study patients = stable KTRs) in comparison with the general population (VGH patients = non-KTRs). A: Insulin secretion by 2-h glucose (left) and insulin sensitivity by 2-h glucose (right). Model shows ordinary least-squares regression analysis of 2-h glucose (independent variable) against (left) insulin AUC and (right) OGIS (dependent variables). Within each of the three patient groups (TIP, TAHG, non-KTRs), 2-h glucose was modeled using a linear spline function with a single knot at 140 mg/dL. P for interaction testing slope difference between stable KTRs and non-KTRs was <0.001 (left) and <0.001 (right). P for interaction testing slope difference between early KTRs and non-KTRs was 0.016 (left) and <0.001 (right). B: Insulin sensitivity by β-cell function (left) in patients with 2-h glucose <140 mg/dL and (right) in patients with 2-h glucose ≥140 mg/dL. Model shows ordinary least-squares regression of IGI (independent variable) against OGIS (dependent variable). Results were centered at the mean OGIS within each category of 2-h glucose. P for interaction testing slope difference between stable KTRs and non-KTRs was 0.21 (left) and 0.05 (right). P for interaction testing slope difference between early KTRs and non-KTRs was 0.06 (right). A and B: Model results for the subgroup of TIP study patients with 2-h glucose <140 mg/dL were hidden because of insufficient sample size. x, Non-KTRs; ○, stable KTRs; ▲, early KTRs.