Figure 1.

Whole-cell K⁺ current and BK channel subunit expression is similar in smooth muscle from wild type (WT) and A₁KO mice. Representative traces of whole-cell K⁺ current in aortic smooth muscle cells from WT (A) and A₁KO mice (B). The voltage template used to elicit the currents in this and subsequent figures is shown below the trace in A; cells were held at −80 mV and stepped from –100 to +100 mV in 20 mV increments. (C) Group data representing whole-cell K⁺ current in aortic smooth muscle cells from WT (n = 13) and A₁KO (n = 20) mice. (D) Representative Western blots from mouse aortae for BK channel subunit expression relative to β -actin (α = 100 kDa; β 1 = 25 kDa; β –actin = 42 kDa). (E) Group data for BK α and β 1 subunit expression in the aortae of WT (n = 6) and A₁KO (n = 6) mice. There were no differences between WT and A₁KO mice in whole-cell K⁺ current or BK protein expression.