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. 2013 Aug 20;8(8):e72822. doi: 10.1371/journal.pone.0072822

Figure 3. Myelination and expression of TCF7L2 in the human CNS.

Figure 3

The extent of myelination in human frontal lobes was quantified using a semiquantitative score. Between 30 and 40 weeks of gestation no MBP-positive axons were found. Myelination became first obvious between 0 and 6 months after birth (A). First TCF7L2-positive cells were detected at the end of gestation with maximal numbers between 7 and 12 months after birth. Afterwards, the numbers of TCF7L2-positive cells decreased quickly (B). At 6 months after birth numerous myelinating oligodendrocytes were observed (immunohistochemistry for MBP) (C). Many TCF7L2 positive cells also expressed NOGOA (double immunohistochemistry for NogoA (red) and TCF7L2 (black) (D) but not GFAP (double immunohistochemistry for TCF7L2 (black) and GFAP (red)) (E). TCF7L2 was also expressed in human fetal oligodendrocytes in vitro (green O4, red TCF7L2) (F).