Table 3. Inflammation under the control of Per2 during myocardial ischemia and reperfusion.
Inflammatory ‘Per2 genes’ I30R60 | Fold change [Exp. Value] |
Resistin-like molecule-beta | 8.02 |
CCL3L1/CCL3L3 | 7.855 |
Metalloproteinase-8 | 5.05 |
Tumor Necrosis Factor | 4.286 |
Immunoresponsive gene 1 | 4 |
Gadd45beta | 3.9 |
S100A8/A9 | 3.919 |
IL1A interleukin 1, alpha | 2.991 |
Interleukin 36, gamma | 2.718 |
Triggering receptor expressed on myeloid cells 1 | 2.386 |
Toll-like receptor 2 | 2.212 |
Interleukin 17 receptor A | 2.2 |
IL1R1 interleukin 1 receptor, type I | 2.112 |
Shown are the top genes accounting for the identification of a dominant pro inflammatory program when analyzing genes that are only regulated in Per2−/− mice using 30 minutes of ischemia and 60 minutes of reperfusion. Given are the expression values (fold change) obtained by Ingenuity pathway analysis. I30R60 = 30 minutes of ischemia and 60 minutes of reperfusion.