Table 3. Effects of fluorene on anxiety-related behavior assessed in the elevated-plus maze.

Variable	Restrained Controls	1.5 ppb	150 ppb	ANOVA
				F(2, 35)	p
Total arm entries	15.4±1.1	15.4±0.8	16.8±1.4	0.471	n.s.
Open arm entries	5.9±0.8	5.7±0.6	5.9±0.6	0.047	n.s.
Closed arm entries	9.5±0.7	9.8±0.9	10.8±0.9	0.713	n.s.
% Open arm entries	37.6±3.1	37.3±4.3	35.0±3.1	0.167	n.s.
Open arm time (s)	87.5±9.7	75.4±12.7	71.7±9.9	0.565	n.s.
Closed arm time (s)	148.7±11.2	147.8±14.8	148.8±10.7	0.998	n.s.
Central area time (s)	63.8±6.3	76.8±5.4 *	79.5±4.6 *	4.352	< 0.05
Total head-dipping	7.7±0.8	8.3±0.9	8.2±1.2	0.902	n.s.
% head-dipping in open arms	62.3±5.7	54.7±7.4	40.0±7.1	2.795	p = 0.08
Total rearing	22.5±1.5	22.3±2.0	25.3±1.2	0.357	n.s.
% rearing in closed arms	69.8±3.5	72.4±4.3	70.5±2.6	0.151	n.s.

Results are expressed as mean ± S.E.M. of n = 12 rats/group. Dunnett's t-test was used for multiple comparisons.

^* p<0.05, statistical significant difference from controls. Abbreviations: n.s., not significant.