Table 5. Effects of fluorene on spatial memory performances assessed in the eight-arm maze.

Group		Day 1	Day 4	Day 8	Day 12	Group of exposure		Time of testing			Group x Time
						F(2, 35)	p	F(2, 35)	p		F(2, 35)	p
Total time (s)
	Restrained Controls	129.7±10.6	86.2±9.6	68.7±4.5	76.1±8.0	1.345	n.s.	20.442	**		0.525	n.s.
	1.5 ppb	119.9±11.7	81.7±8.6	72.9±4.3	69.2±2.5
	150 ppb	132.0±13.5	76.2±3.9	69.9±4.1	56.3±3.2
Total arm entries
	Restrained Controls	12.2±0.7	9.8±0.6	9.3±0.6	9.4±0.8	0.419	n.s.	12.396	**	0.323		n.s.
	1.5 ppb	12.3±1.3	9.8±0.6	9.1±0.3	8.5±0.2
	150 ppb	12.6±1.1	10.2±0.6	9.3±0.5	8.3±0.2
Arm entries before the 1st error
	Restrained Controls	5.8±0.4	6.8±0.4	6.5±0.5	6.9±0.5	0.503	n.s.	11.51	**	0.91		n.s.
	1.5 ppb	5.4±0.6	6.7±0.4	7.2±0.2	7.3±0.3
	150 ppb	4.5±0.6	6.2±0.5	7.4±0.3	6.8±0.6
Number of arm visited/min
	Restrained Controls	5.7±0.3	7.1±0.4	7.7±0.2	7.3±0.5	2.497	n.s.	22.901	**	0.388		n.s.
	1.5 ppb	5.9±0.6	7.3±0.4	8.0±0.3	7.6±0.1
	150 ppb	6.1±0.5	8.1±0.4	8.1±0.3	9.3±0.2

Results are expressed as mean ± S.E.M. of n = 12 rats/group. ** p<0.01, statistical significant variation (two-way ANOVA with repeated measures as one factor). Abbreviations: n.s., not significant.