Table 1. ITC Derived Thermodynamic Parameters for the binding of porphyrin ligands (TMPyP2, TMPyP3, and TMPyP4) to the 39Bcl-2 promoter sequence G-Quadruplex.
Ligand | K1 ×10-5 | ΔG1 (kcal/mol) | ΔH1 (kcal/mol) | -TΔS1 (kcal/mol) | K2 ×10-5 | ΔG2 (kcal/mol) | ΔH2 (kcal/mol) | -TΔS2 (kcal/mol) |
---|---|---|---|---|---|---|---|---|
TMPyP2 | 0.7 ± 0.5 | -6.6 | -0.6 ± 0.2 | -6.0 | - | - | - | - |
TMPyP3 | 2.6 ± 0.5 | -7.4 | -4.1 ± 0.1 | -3.3 | - | - | - | - |
TMPyP4 | 37.0 ± 4.0 | -9.0 | -4.2 ± 0.1 | -4.7 | 0.9 ± 0.5 | -6.7 | -9.8 ± 0.1 | -3.1 |