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. 2013 Aug 20;8(8):e71880. doi: 10.1371/journal.pone.0071880

Figure 4. D1/5R antagonist blocks the effect of D1/5R or DA on neuronal excitability and post-burst AHP.

Figure 4

(A) An example of the effect of D1/5 receptor agonist SKF81297 (10 µM) on neuronal excitability (left) and post-burst AHP (right) in the presence of D1/5 receptor antagonist SCH23390 (10 µM). The protocols for excitability test and post-burst AHP recording were run alternately every 30 seconds. (B) Excitability before, during and after 15-min application of SKF81297 in the presence of SCH23390 (left). Group histograms showing that SKF81297 or DA does not suppress the neuronal excitability of mPFC neurons in the presence of SCH23390 (right) (p>0.05 for SKF81297+SCH23390 vs. baseline; p>0.05 for DA+ SCH23390 vs. baseline, paired t-test). (C) Amplitude of post-burst AHP before, during and after 15-min application of SKF81297 in the presence of SCH23390 (left). Group histograms showing that SKF81297 or DA does not suppress the amplitude of post-burst AHP in the presence of SCH23390 (right) (p>0.05 for SKF81297+ SCH23390 vs. baseline; p>0.05 for DA+ SCH23390 vs. baseline, paired t-test). (D) Area of post-burst AHP before, during and after 15-min application of the SKF81297 in the presence of SCH23390 (left). Group histograms showing that SKF81297 or DA does not suppress the area of post-burst AHP in the presence of SCH23390 (right) (p>0.05 for SKF81297+ SCH23390 vs. baseline; p>0.05 for DA+ SCH23390 vs. baseline, paired t-test).