Skip to main content
. 2013 Aug 20;8(8):e71880. doi: 10.1371/journal.pone.0071880

Figure 7. DA and D1/5 regulation of excitability and post-burst AHP does not involve HCN.

Figure 7

(A) An example of the effect of DA (30 µM) on neuronal excitability (left) and post-burst AHP (right) in the presence of HCN blocker ZD7288 (20 µM). The protocols for excitability test and post-burst AHP recording were run alternately every 30 seconds. (B) Excitability before, during and after 15-min application of the DA in the presence of ZD7288 (left). Group histograms showing that DA (30 µM) or D1/5 receptor agonist SKF81297 (10 µM) enhances the neuronal excitability of mPFC neurons in the presence of HCN blocker ZD7288 (right) (**p<0.01 for ZD7288+DA vs. baseline; **p<0.01 for ZD7288+SKF81297 vs. baseline; paired t-test). (C) Amplitude of post-burst AHP before, during and after 15-min application of the DA in the presence of ZD7288 (left). Group histograms showing that DA (30 µM) or D1/5 receptor agonist SKF81297 (10 µM) reduces the amplitude of post-burst AHP in the presence of ZD7288 (right) (**p<0.01 for ZD7288+DA vs. baseline; **p<0.01 for ZD7288+SKF81297 vs. baseline; paired t-test). (D) Decay time of post-burst AHP before, during and after 15-min application of the DA in the presence of ZD7288 (left). Group histograms showing that DA (30 µM) or D1/5 receptor agonist SKF81297 (10 µM) reduces the decay time of post-burst AHP in the presence of ZD7288 (right) (**p<0.01 for ZD7288+DA vs. baseline; **p<0.01 for ZD7288+SKF81297 vs. baseline; paired t-test).