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. 2013 Aug 20;8(8):e71880. doi: 10.1371/journal.pone.0071880

Figure 8. DA and D1/5 regulation of post-burst afterdepolarizing potentials.

Figure 8

(A) An example of the effect of DA (30 µM) on afterdepolarizing potentials (ADP). (B) Amplitude of ADP before, during and after 15-min application of the DA in the absence (left) or in the presence of HCN blocker ZD7288 (20 µM) (middle). Group histograms showing DA enlarges the amplitude of ADP in the absence or in the presence of ZD7288 (right) (**p<0.01 for DA vs. baseline; **p<0.01 for DA+ZD7288 vs. baseline, paired t-test) (p>0.05 for DA+ZD7288 vs. DA, one way ANOVA). (C) Amplitude of ADP before, during and after 15-min application of SKF81297 in the absence (left) or in the presence of HCN blocker ZD7288 (middle). Group histograms showing that SKF81297 enlarges the amplitude of ADP in the absence or in the presence of HCN blocker ZD7288 (right) (**p<0.01 for SKF81297 vs. baseline; **p<0.01 for SKF81297+ZD7288 vs. baseline, paired t-test) (p>0.05 for SKF81297+ZD7288 vs. SKF81297, one way ANOVA).