Table 2.

Molecular abnormalities with prognostic value in normal cytogenetic AML.

Molecular abnormality	Frequency	Effect on prognosis (+/−)
FLT3	28%–34%	−
NPM1	45%–60%*	+
CEBP alpha	10%–18%	+
DNMT3A	20%–30%	−
IDH1 or 2	10%–19%	+
TET2	25%**	?***
EVI1	10%	−
ERG	25%	−
MN1	50%	−
BAALC	65.7%	−

Notes:

^*Has favorable prognosis in absence of FLT3;

^**in secondary AML. Frequency in de-novo AML under investigation;

^***unfavorable in most reports.

Adapted from Marcucci 2012¹³³ and Gregory 2009.¹³⁴