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A. Sample current records. Control, (c); 10µM retigabine, (r). Calibration: pA total current. Note that retigabine slows current deactivation and accelerates current activation as previously observed [25]. B, Mean % increase in standing outward current at −20 mV in +/+, +/− and −/− neurons (with numbers of neurons in brackets). *- indicates significant difference from wild type (P<0.01).
