Table 2. Prognostic effect of the ratio of nuclear to cytoplasmic FOXP3⁺CD4⁺ cells, adjusted for baseline characteristics.

	#Adjusted effect of %nFOXP3+/cFOXP3+			Covariate effect
Model covariate	OR	95% CI	p-value	OR	95% CI	p-value
Age a surgery: ≥64 vs ≤63 years	9.2	(1.7 to 48.9)	0.009	5.4	(0.5 to 62.9)	0.178
Gender: female vs male	8.4	(2.0 to 35.5)	0.004	4.7	(0.5 to 49.2)	0.194
Race: Hispanic vs white nonHispanic	6.3	(1.9 to 20.5)	0.003	0.7	(0.1 to 6.8)	0.739
Current or former use of tobacco and alcohol:	7.2	(1.9 to 27.2)	0.004	–	–	–
Tobacco only	–	–	–	0.2	(0.01 to 5.2)	0.301
Alcohol only	–	–	–	1.0	(0.0 to 478.2)	0.989
both	–	–	–	0.3	(0.02 to 5.0)	0.429
T-stage: T-2 vs T-1	8.2	(2.2 to 30.9)	0.002	9.1	(0.7 to 124.5)	0.097
Grade: mod/poor differentiation v well differentiated	6.5	(1.9 to 21.8)	0.002	4.2	(0.5 to 35.5)	0.193

OR: Odds ratio. CI: Confidence interval. p-value:Wald test.

^#Risk of recurrence per twofold increase in ratio of nuclear to cytoplasmic FOXP3⁺CD4⁺ cells, adjusted for covariate shown at left.