Figure 5.
Upregulation of fibronectin and its integrin receptors on cerebral vessels in the ischemic penumbra seven days after focal cerebral ischemia. Frozen sections of ischemic penumbra or contralateral hemisphere were examined for vascular expression of: (A) fibronectin, (B) α5 integrin, or (C) β3 integrin. Scale bar = 50 μm. Note that while few vessels in the contralateral hemisphere expressed fibronectin or its receptors, vessels in the ischemic penumbra strongly upregulated fibronectin and the α5 and β3 integrins (D).