Table 1. Effect of 0.1 µmol/L ketotifen and 0.1 mmol/L tranilast on basal and EFS-induced histamine and NA release.
|
Histamine release
|
NA release
|
|||
|---|---|---|---|---|
| Basal | EFS | Basal | EFS | |
| Control | 0.51 + 0.15 | 1.19 + 0.27* | 6.65 + 0.99 | 9.25 + 1.13* |
| Ketotifen | 0.15 + 0.03# | 0.38 + 0.16*# | 6.67 + 0.60 | 9.33 + 0.88* |
| Tranilast | 0.19 + 0.02# | 0.52 + 0.11*# | 6.55 + 0.65 | 8.89 + 1.05* |
| TTX | 0.58 + 0.09 | 0.66 + 0.17# | 6.37 + 0.74 | 6.45 + 0.87# |
This table presents histamine and NA levels released in basal and EFS conditions. Results (means + SEM) are expressed as nmol histamine /mL mg tissue, or ng NA/mL mg tissue. *P< 0.05 vs basal conditions. #P< 0.05 vs control. n= 6 animals each group.