. Author manuscript; available in PMC: 2014 Feb 1.

Published in final edited form as: Obesity (Silver Spring). 2013 May 10;21(8):1704–1712. doi: 10.1002/oby.20111

Table 3.

Association of pericardial fat and intra-thoracic fat with CAC prevalence and progression

	Prevalent CAC^a OR (95% CI) n=598	p-value	CAC ordinal^a OR (95% CI) n=598	p-value	CAC progression^a OR (95% CI) n=452	p-value
Pericardial Fat ^b
Age, race/gender	1.54 (1.22, 1.97)	0.0005	1.30 (1.10, 1.53)	0.002	1.11 (0.88, 1.40)	0.39
+BMI, Smoking, Exercise	1.40 (1.07, 1.82)	0.01	1.17 (0.98, 1.41)	0.08	0.98 (0.75, 1.27)	0.86
+HTN, Diabetes, Lipids	1.28 (0.97, 1.70)	0.08	1.06 (0.88, 1.29)	0.52	0.94 (0.71, 1.25)	0.67
+Adipocytokines	1.28 (0.95, 1.72)	0.11	1.04 (0.86, 1.27)	0.69	1.00 (0.74, 1.34)	0.97
+Visceral Fat	1.20 (0.84, 1.71)	0.32	1.00 (0.79, 1.26)	0.99	1.09 (0.77, 1.55)	0.64
Intra-Thoracic Fat ^b
Age, race/gender	4.07 (2.14, 7.74)	<0.001	2.16 (1.52, 3.06)	<0.001	1.58 (0.95, 2.62)	0.08
+BMI, Smoking, Exercise	3.41 (1.70, 6.81)	0.0005	1.85 (1.26, 2.72)	0.002	1.30 (0.73, 2.29)	0.37
+HTN, Diabetes, Lipids	2.79 (1.39, 5.60)	0.004	1.62 (1.09, 2.41)	0.02	1.16 (0.64, 2.10)	0.64
+Adipocytokines	2.94 (1.40, 6.18)	0.004	1.69 (1.11, 2.57)	0.02	1.10 (0.59, 2.09)	0.75
+Visceral Fat	3.84 (1.54, 9.58)	0.004	1.95 (1.16, 3.28)	0.01	1.70 (0.76, 3.79)	0.19

Prevalent CAC is CAC in Agatston units >0 at Visit 8; CAC ordinal is CAC in Agatston units at Visit 8 categorized 0, 1-100, 101-300, >300; CAC progression is defined by Hokanson method, i.e. sqrt(Visit 10 CAC volume – Visit 8 CAC volume) ≥ 2.5 cm³ is considered progression

Per standard deviation higher – pericardial fat 22.7 cm³, intra-thoracic fat 19.5 cm³