Table 3.
Prevalent CACa OR (95% CI) n=598 |
p-value | CAC ordinala OR (95% CI) n=598 |
p-value | CAC progressiona OR (95% CI) n=452 |
p-value | |
---|---|---|---|---|---|---|
Pericardial Fat b | ||||||
Age, race/gender | 1.54 (1.22, 1.97) | 0.0005 | 1.30 (1.10, 1.53) | 0.002 | 1.11 (0.88, 1.40) | 0.39 |
+BMI, Smoking, Exercise | 1.40 (1.07, 1.82) | 0.01 | 1.17 (0.98, 1.41) | 0.08 | 0.98 (0.75, 1.27) | 0.86 |
+HTN, Diabetes, Lipids | 1.28 (0.97, 1.70) | 0.08 | 1.06 (0.88, 1.29) | 0.52 | 0.94 (0.71, 1.25) | 0.67 |
+Adipocytokines | 1.28 (0.95, 1.72) | 0.11 | 1.04 (0.86, 1.27) | 0.69 | 1.00 (0.74, 1.34) | 0.97 |
+Visceral Fat | 1.20 (0.84, 1.71) | 0.32 | 1.00 (0.79, 1.26) | 0.99 | 1.09 (0.77, 1.55) | 0.64 |
Intra-Thoracic Fat b | ||||||
Age, race/gender | 4.07 (2.14, 7.74) | <0.001 | 2.16 (1.52, 3.06) | <0.001 | 1.58 (0.95, 2.62) | 0.08 |
+BMI, Smoking, Exercise | 3.41 (1.70, 6.81) | 0.0005 | 1.85 (1.26, 2.72) | 0.002 | 1.30 (0.73, 2.29) | 0.37 |
+HTN, Diabetes, Lipids | 2.79 (1.39, 5.60) | 0.004 | 1.62 (1.09, 2.41) | 0.02 | 1.16 (0.64, 2.10) | 0.64 |
+Adipocytokines | 2.94 (1.40, 6.18) | 0.004 | 1.69 (1.11, 2.57) | 0.02 | 1.10 (0.59, 2.09) | 0.75 |
+Visceral Fat | 3.84 (1.54, 9.58) | 0.004 | 1.95 (1.16, 3.28) | 0.01 | 1.70 (0.76, 3.79) | 0.19 |
Prevalent CAC is CAC in Agatston units >0 at Visit 8; CAC ordinal is CAC in Agatston units at Visit 8 categorized 0, 1-100, 101-300, >300; CAC progression is defined by Hokanson method, i.e. sqrt(Visit 10 CAC volume – Visit 8 CAC volume) ≥ 2.5 cm3 is considered progression
Per standard deviation higher – pericardial fat 22.7 cm3, intra-thoracic fat 19.5 cm3